During European afternoon trade, the EURO STOXX 50 slid 0.32%, France's CAC 40 retreated 0.58%, while Germany's DAX 30 slipped 0.10%.
Data earlier showed that the Sentix index of euro zone investor confidence rose to a six month high of 6.5 in September, up from minus 4.9 last month. Analysts had forecast a reading of minus 2.8.
But concerns over a possible conflict in Syria persisted after Syrian President Bashar al-Assad over the weekend denied authorizing a chemical weapons attack on his own citizens.
The comments came as the U.S. government was set to vote this week on President Barack Obama's proposal to launch a missile strike.
Financial stocks remained mixed, as BNP Paribas slid 0.49% and Societe Generale advanced 0.82% in France, while Germany's Deutsche Bank rose 0.37%.
Among peripheral lenders, Spanish banks Banco Santander and BBVA declined 0.76% and 0.92% respectively, while Italy's Intesa Sanpaolo and Unicredit rallied 0.91% and 2.05%.
Elsewhere, Royal KPN edged down 0.14% after the Dutch phone carrier, subject of a takeover proposal by America Movil, said Chief Financial Officer Eric Hageman is stepping down for personal reasons.
In London, FTSE 100 shed 0.52%.
Financial stocks remained mostly higher, as shares in the Royal Bank of Scotland gained 0.64% and Barclays climbed 0.40%, while Lloyds Banking jumped 1.20%.
Meanwhile, mining stocks turned broadly upward. Glencore Xstrata and Fresnillo rallied 1.15% and 2.25% respectively, while Eurasian Natural Resources added 0.09%, erasing earlier losses.
In the U.S., equity markets pointed to a higher open. The Dow Jones Industrial Average futures pointed to a 0.21% gain, S&P 500 futures signaled a 0.24% rise, while the Nasdaq 100 futures indicated a 0.44% increase.
In addition, improved trade data out of China over the weekend added to indications that the world's second largest economy is recovering from a slowdown. Data on Sunday showed that Chinese exports were 7.2% higher year-over-year in August, up from 5.1% in July, and imports were up 7%.
Data on Monday showed that Chinese consumer price inflation was up 2.6% year-on-year in August, in line with expectations.
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